Biomechanics of Traumatic
Rapid-stretch Nerve Injury

The majority of traumatic peripheral nerve injuries are due to a mechanism of rapid-stretch. This mechanism is characterized by rapid-acceleration followed by abrupt deceleration. Such trauma is commonly associated with motor vehicle accidents, extreme sports such as skiing and biking, and even obstetrical trauma. Unfortunately, no biofidelic model exists to replicate this human condition in the laboratory. Without a relevant clinical model, therapeutic outcomes remain limited.

Novel Model

In order to address the dearth in a clinically relevant laboratory model, we developed a novel testing apparatus allowing in-vivo rapid-stretch of nerves. Mimicking the clinically relevant mechanism of injury

Reproducible Injury Grades Derived from Biomechanical Properties​

Our assessment of rate, loading direction, and excursion revealed regional variations in the architectural compliance of nerves. Further, biomechanical measurements generated reproducible injury grades. 

Why it Matters

Considering the potential for regeneration in the peripheral nervous system, We fail both basic science and our patients with a dearth of knowledge within this discipline. Our model and research provides the scaffold to better understand the microenvironment of injury and repair after rapid-stretch injury. Elucidating the body’s response to this trauma will drive therapeutic development germane to the clinical condition with the ultimate goal to provide better outcomes for our patients.

Publication

Neurosurgery